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Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice

Hussain, Ainy Khan

Description

Leptin is an important adipokine involved in the regulation of food intake and energy homeostasis. In the absence of leptin or its functional receptors, rodents and humans develop a variety of metabolic dysfunctions, including decreased energy expenditure, severe insulin resistance, diabetes, dyslipidaemia and increased body weight. Leptin also has several extra-hypothalamic effects, and its neurogenic actions regulate anxiety and depression-like behaviours. Moreover, leptin deficiency leads to...[Show more]

CollectionsOpen Access Theses
Date published: 2012
Type: Thesis (MPhil)
URI: http://hdl.handle.net/1885/149840
DOI: 10.25911/5d5fc93576a1a
Access Rights: Open Access

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