Adipose tissue transplantation improves metabolic, behavioural and histological parameters in leptin-deficient mice
Leptin is an important adipokine involved in the regulation of food intake and energy homeostasis. In the absence of leptin or its functional receptors, rodents and humans develop a variety of metabolic dysfunctions, including decreased energy expenditure, severe insulin resistance, diabetes, dyslipidaemia and increased body weight. Leptin also has several extra-hypothalamic effects, and its neurogenic actions regulate anxiety and depression-like behaviours. Moreover, leptin deficiency leads to...[Show more]
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