Angular naphthopyrones as antibacterial agents : investigations into the antibacterial activity of benzo[f]chromanones and related compounds
Antibiotics have been hailed as one of medicine's greatest achievements, but the effectiveness of current drugs is waning. Chapter 1 introduces the need for novel antibacterials, current approaches towards drug discovery, and the suitability of benzo[f]chromanone as a scaffold for antibacterial drug development. A summary of synthetic methods for the preparation of benzo[f]chromanones IS presented in Chapter 2. The suitability of polyphosphoric acid (PPA) cyclisation methodology was...[Show more]
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