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Identification and analysis of regulators of the epithelial to mesenchymal transition using Drosophila wing disc eversion

Manhire-Heath, Rosemary


The epithelial to mesenchymal transition (EMT), the process where epithelial cells break free from their adhesive connections and become migratory, is a key mechanism in development and disease. To discover new EMT regulators, wing disc eversion was developed as a model system to enable RNAi screening, in vivo, in Drosophila. During eversion, a population of wing imaginal disc cells, the peripodial cells, lose apico-basal polarity, adherens junctions, breakdown the basement membrane, then...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)


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