Identification and analysis of regulators of the epithelial to mesenchymal transition using Drosophila wing disc eversion
The epithelial to mesenchymal transition (EMT), the process where epithelial cells break free from their adhesive connections and become migratory, is a key mechanism in development and disease. To discover new EMT regulators, wing disc eversion was developed as a model system to enable RNAi screening, in vivo, in Drosophila. During eversion, a population of wing imaginal disc cells, the peripodial cells, lose apico-basal polarity, adherens junctions, breakdown the basement membrane, then...[Show more]
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