Skip navigation
Skip navigation

Identification and analysis of regulators of the epithelial to mesenchymal transition using Drosophila wing disc eversion

Manhire-Heath, Rosemary

Description

The epithelial to mesenchymal transition (EMT), the process where epithelial cells break free from their adhesive connections and become migratory, is a key mechanism in development and disease. To discover new EMT regulators, wing disc eversion was developed as a model system to enable RNAi screening, in vivo, in Drosophila. During eversion, a population of wing imaginal disc cells, the peripodial cells, lose apico-basal polarity, adherens junctions, breakdown the basement membrane, then...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/149752

Download

File Description SizeFormat Image
b30953479_Manhire-Heath_Rosemary.pdf60.17 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator