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The role of complement in a new mouse model of focal retinal degeneration

Jiao, Helen

Description

Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss that poses a major health problem with substantial socioeconomic implications. The more prevalent form of AMD is atrophic or ‘dry’ AMD with limited treatment available. Despite the multifactorial nature of AMD pathogenesis, a key role for inflammation, which involves the recruitment of retinal microglia and macrophages and activation of the complement cascade, is the most...[Show more]

CollectionsOpen Access Theses
Date published: 2018
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/149417
DOI: 10.25911/5d611de917770

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