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An integrated Bayesian analysis of LOH and copy number data

Rancoita, Paola M. V.; Hutter, Marcus; Bertoni, Francesco; Kwee, Ivo

Description

BACKGROUND Cancer and other disorders are due to genomic lesions. SNP-microarrays are able to measure simultaneously both genotype and copy number (CN) at several Single Nucleotide Polymorphisms (SNPs) along the genome. CN is defined as the number of DNA copies, and the normal is two, since we have two copies of each chromosome. The genotype of a SNP is the status given by the nucleotides (alleles) which are present on the two copies of DNA. It is defined homozygous or heterozygous if the two...[Show more]

CollectionsANU Research Publications
Date published: 2010-06-15
Type: Journal article
URI: http://hdl.handle.net/1885/14904
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-11-321

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