Candidate Sequence Variants for Polyautoimmunity and Multiple Autoimmune Syndrome from a Colombian Genetic Isolate: Implications for Population Genetics
Autoimmunity is an immunological disorder whereby patients have lost immunological tolerance to self-antigen. It has extreme financial and socioeconomic burden with costs of over 100 billion dollars in the USA alone, and an estimated prevalence of 9.4%, and evidence indicates that this estimate has increased at a rate of 5% per year for the past 3 years. These phenotypes can be manifested in more severe forms through polyautoimmunity, whereby patients are...[Show more]
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