Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00am and 8:15am on Monday, 9th December 2019.

Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins

Pilla, Kala Bharath; Otting, Gottfried; Huber, Thomas


Pseudocontact shifts (PCSs) induced by paramagnetic lanthanides produce pronounced effects in nuclear magnetic resonance spectra, which are easily measured and which deliver valuable long-range structure restraints. Even sparse PCS data greatly enhance the success rate of 3D (3-dimensional) structure predictions of proteins by the modeling program Rosetta. The present work extends this approach to 3D structures of larger proteins, comprising more than 200 residues, which are difficult to model...[Show more]

CollectionsANU Research Publications
Date published: 2016-01-29
Type: Journal article
Source: Journal of molecular biology
DOI: 10.1016/j.jmb.2016.01.007


File Description SizeFormat Image
JMolBiol2016_428_522.pdf5.22 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator