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Pseudocontact Shift-Driven Iterative Resampling for 3D Structure Determinations of Large Proteins

Pilla, Kala Bharath; Otting, Gottfried; Huber, Thomas

Description

Pseudocontact shifts (PCSs) induced by paramagnetic lanthanides produce pronounced effects in nuclear magnetic resonance spectra, which are easily measured and which deliver valuable long-range structure restraints. Even sparse PCS data greatly enhance the success rate of 3D (3-dimensional) structure predictions of proteins by the modeling program Rosetta. The present work extends this approach to 3D structures of larger proteins, comprising more than 200 residues, which are difficult to model...[Show more]

CollectionsANU Research Publications
Date published: 2016-01-29
Type: Journal article
URI: http://hdl.handle.net/1885/148496
Source: Journal of molecular biology
DOI: 10.1016/j.jmb.2016.01.007

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