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Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid

Welegedara, Adarshi P; Adams, Luke A; Graham, Bim; Otting, Gottfried; Huber, Thomas


Selenocysteine (Sec) is a naturally occurring amino acid that is also referred to as the 21st amino acid. Site-specific incorporation of Sec into proteins is attractive, because the reactivity of a selenol group exceeds that of a thiol group and thus allows site-specific protein modifications. It is incorporated into proteins by an unusual enzymatic mechanism which, in E. coli and other organisms, involves the recognition of a selenocysteine insertion sequence (SECIS) in the mRNA of the target...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-18
Type: Journal article
Source: Bioconjugate chemistry
DOI: 10.1021/acs.bioconjchem.8b00254


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