Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00am and 8:15am on Monday, 9th December 2019.

Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid

Welegedara, Adarshi P; Adams, Luke A; Graham, Bim; Otting, Gottfried; Huber, Thomas

Description

Selenocysteine (Sec) is a naturally occurring amino acid that is also referred to as the 21st amino acid. Site-specific incorporation of Sec into proteins is attractive, because the reactivity of a selenol group exceeds that of a thiol group and thus allows site-specific protein modifications. It is incorporated into proteins by an unusual enzymatic mechanism which, in E. coli and other organisms, involves the recognition of a selenocysteine insertion sequence (SECIS) in the mRNA of the target...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-18
Type: Journal article
URI: http://hdl.handle.net/1885/148490
Source: Bioconjugate chemistry
DOI: 10.1021/acs.bioconjchem.8b00254

Download

File Description SizeFormat Image
BioconjugateChem2018_19_2257.pdf1.25 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator