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Site-selective tagging of proteins by pnictogen-mediated self-assembly

Nitsche, Christoph; Mahawaththa, Mithun C; Becker, Walter; Otting, Gottfried; Huber, Thomas

Description

Site-selective chemical protein modification is achieved by self-assembly of a specific di-cysteine motif, trivalent pnictogens (As, Sb or Bi) and an aromatic mercaptomethyl-based probe. The strategy is demonstrated with a quaternary complex involving Zika virus protease and a lanthanide ion, enabling paramagnetic nuclear magnetic resonance spectroscopy and luminescence measurements.

CollectionsANU Research Publications
Date published: 2017-10-03
Type: Journal article
URI: http://hdl.handle.net/1885/148488
Source: Chemical communications
DOI: 10.1039/c7cc06155b
Access Rights: Open Access

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