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Substrate and cofactor promiscuity of the F₄₂₀ dependent reductases

Lapalikar, Gauri Vijay

Description

Aflatoxins are polyaromatic mycotoxins contaminating a range of food crops, resulting in health problems due to their carcinogenic and toxic properties. Aflatoxins can be metabolized by a group of M. smegmatis enzymes called the F420 dependent reductases (FDRs) which utilise the unusual cofactor F420H2. The FDRs fall into two distinct but related families termed the FDR-As and FDR-Bs, the nearest relatives of both being the structurally similar flavin mononucleotide (FMN) dependent pyridoxamine...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/148263
DOI: 10.25911/5d63bff263266

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