Substrate and cofactor promiscuity of the F₄₂₀ dependent reductases
Aflatoxins are polyaromatic mycotoxins contaminating a range of food crops, resulting in health problems due to their carcinogenic and toxic properties. Aflatoxins can be metabolized by a group of M. smegmatis enzymes called the F420 dependent reductases (FDRs) which utilise the unusual cofactor F420H2. The FDRs fall into two distinct but related families termed the FDR-As and FDR-Bs, the nearest relatives of both being the structurally similar flavin mononucleotide (FMN) dependent pyridoxamine...[Show more]
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