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Experimental and kinetic studies of the escherichia coli glucuronylsynthase : an engineered enzyme for the synthesis of glucuronides

Wilkinson, Shane Michael


The E. coli glucuronylsynthase is a glycosynthase enzyme derived from E. coli {u03B2}-glucuronidase. It catalyses the conjugation of a glucopyranuronic acid unit to an alcohol acceptor. These glucuronide conjugates are important markers for doping in sports drug testing and drug metabolism in pharmaceutical trials. Up till now, the optimal glucuronylsynthase reaction conditions were unknown which may have reduced the previously reported yields. This thesis covers the development and...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
DOI: 10.25911/5d63c17820542


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