14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
Schoenwaelder, Simone M; Darbousset, Roxane; Cranmer, Susan L; Ramshaw, Hayley S; Orive, Stephanie L; Sturgeon, Sharelle; Yuan, Yuping; Yao, Yu; Krycer, James R; Woodcock, Joanna; Maclean, Jessica; Pitson, Stuart; Zheng, Zhaohua; Henstridge, Darren C; van der Wal, Dianne; Gardiner, Elizabeth; Berndt, Michael C; Andrews, Robert K; James, David E; Lopez, Angel F; Jackson, Shaun P
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which has previously been implicated in regulating GPIbα function. Here we show an important role for 14-3-3ζ in regulating arterial thrombosis. Interestingly, this thrombosis defect is not related to alterations in von Willebrand factor (VWF)-GPIb adhesive function or platelet activation, but...[Show more]
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