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Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

Spillman, Natalie; Dalmia, Varun K; Goldberg, Daniel E

Description

Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream. Bioactive EETs are hydrolyzed to less active diols (dihydroxyeicosatrienoic acids) by epoxide hydrolases (EHs). The malaria parasite Plasmodium falciparum infects host red blood cells (RBCs) and exports hundreds of proteins into the RBC compartment. In this study, we show that two...[Show more]

CollectionsANU Research Publications
Date published: 2016-10-18
Type: Journal article
URI: http://hdl.handle.net/1885/147280
Source: mBio
DOI: 10.1128/mBio.01538-16
Access Rights: Open Access

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