Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents
The basic mechanism of the major neurodegenerative diseases, including neurogenic pain, needs to be agreed upon before rational treatments can be determined, but this knowledge is still in a state of flux. Most have agreed for decades that these disease states, both infectious and non-infectious, share arguments incriminating excitotoxicity induced by excessive extracellular cerebral glutamate. Excess cerebral levels of tumor necrosis factor (TNF) are also documented in the same group of...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of neuroinflammation|
|Access Rights:||Open Access|
|01 Clark Ian A and Vissel B Excess cerebral TNF 2016.pdf||1.68 MB||Adobe PDF|
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