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Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

Clark, Ian A; Vissel, Bryce


The basic mechanism of the major neurodegenerative diseases, including neurogenic pain, needs to be agreed upon before rational treatments can be determined, but this knowledge is still in a state of flux. Most have agreed for decades that these disease states, both infectious and non-infectious, share arguments incriminating excitotoxicity induced by excessive extracellular cerebral glutamate. Excess cerebral levels of tumor necrosis factor (TNF) are also documented in the same group of...[Show more]

CollectionsANU Research Publications
Date published: 2016-09-05
Type: Journal article
Source: Journal of neuroinflammation
DOI: 10.1186/s12974-016-0708-2
Access Rights: Open Access


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