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Differential HbA1c response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries: a systematic review and meta-analysis

He, Lingyu; Liu, Shu; Shan, Chun; Tu, Yingmei; Li, Zhengqing; Zhang, Xiaohua Douglas

Description

BACKGROUND It has been observed that the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors as compared to the placebo groups in some clinical trials conducted in China is weaker than that in trials conducted outside China, leading to the suspicion that this may be caused by differential Glycosylated Hemoglobin (HbA1c) response in the placebo arm of DPP-4 inhibitor clinical trials conducted in China compared to other countries. METHODS We searched published articles and other documents...[Show more]

CollectionsANU Research Publications
Date published: 2016-09-07
Type: Journal article
URI: http://hdl.handle.net/1885/147266
Source: BMC pharmacology & toxicology
DOI: 10.1186/s40360-016-0084-7
Access Rights: Open Access

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