Hewawasam, Ruwani P; Liu, Dan; Casarotto, Marco G; Board, Philip G; Dulhunty, Angela
The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II detoxification enzymes with additional functions including the selective inhibition of RyR2, with therapeutic implications. The C-terminal half of GSTM2 (GSTM2C) is essential for RyR2 inhibition, and mutations F157A and Y160A within GSTM2C prevent...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.