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The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes

Hewawasam, Ruwani P; Liu, Dan; Casarotto, Marco G; Board, Philip G; Dulhunty, Angela

Description

The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) are a family of phase II detoxification enzymes with additional functions including the selective inhibition of RyR2, with therapeutic implications. The C-terminal half of GSTM2 (GSTM2C) is essential for RyR2 inhibition, and mutations F157A and Y160A within GSTM2C prevent...[Show more]

CollectionsANU Research Publications
Date published: 2016-09-09
Type: Journal article
URI: http://hdl.handle.net/1885/147255
Source: PloS one
DOI: 10.1371/journal.pone.0162415
Access Rights: Open Access

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