Skip navigation
Skip navigation

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Guo, Linna; Zaysteva, Olga; Nie, Zuqin; Mitchell, Naomi C; Amanda Lee, Jue Er; Ware, Thomas; Parsons, Linda; Luwor, Rodney; Poortinga, Gretchen; Hannan, Ross D; Levens, David L; Quinn, Leonie M

Description

Despite two decades of research, the major function of FBP-family KH domain proteins during animal development remains controversial. The literature is divided between RNA processing and transcriptional functions for these single stranded nucleic acid binding proteins. Using Drosophila, where the three mammalian FBP proteins (FBP1-3) are represented by one ortholog, Psi, we demonstrate the primary developmental role is control of cell and tissue growth. Co-IP-mass spectrometry positioned Psi in...[Show more]

CollectionsANU Research Publications
Date published: 2016-05-20
Type: Journal article
URI: http://hdl.handle.net/1885/147094
Source: Nucleic acids research
DOI: 10.1093/nar/gkw461
Access Rights: Open Access

Download

File Description SizeFormat Image
01 Guo L et al Defining the essential 2016.pdf1.65 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator