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Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Guo, Linna; Zaysteva, Olga; Nie, Zuqin; Mitchell, Naomi C; Amanda Lee, Jue Er; Ware, Thomas; Parsons, Linda; Luwor, Rodney; Poortinga, Gretchen; Hannan, Ross D; Levens, David L; Quinn, Leonie M


Despite two decades of research, the major function of FBP-family KH domain proteins during animal development remains controversial. The literature is divided between RNA processing and transcriptional functions for these single stranded nucleic acid binding proteins. Using Drosophila, where the three mammalian FBP proteins (FBP1-3) are represented by one ortholog, Psi, we demonstrate the primary developmental role is control of cell and tissue growth. Co-IP-mass spectrometry positioned Psi in...[Show more]

CollectionsANU Research Publications
Date published: 2016-05-20
Type: Journal article
Source: Nucleic acids research
DOI: 10.1093/nar/gkw461
Access Rights: Open Access


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