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Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease

Su, Yung-Chang; Townsend, Dijana; Herrero, Lara J.; Zaid, Ali; Rolph, Michael S.; Gahan, Michelle E.; Nelson, Michelle A.; Rudd, Penny A.; Matthaei, Klaus I.; Foster, Paul S.; Dent, Lindsay; Tripp, Ralph A.; Lee, James; Simson, Ljubov; Mahalingam, Suresh

Description

Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown that vaccination with formalin-inactivated RSV (FI-RSV) leads to prominent airway eosinophilic inflammation following RSV challenge; however, the roles of pulmonary eosinophilia in the antiviral response...[Show more]

CollectionsANU Research Publications
Date published: 2015-02
Type: Journal article
URI: http://hdl.handle.net/1885/14674
Source: Journal of Virology
DOI: 10.1128/JVI.01536-14

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