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13C and 15N natural isotope abundance reflects breast cancer cell metabolism

Tea, Illa; Martineau, Estelle; Antheaume, Ingrid; Lalande, Julie; Mauve, Caroline; Gilard, Francoise; Barillé-Nion, Sophie; Blackburn, Anneke; Tcherkez, Guillaume


Breast cancer is the most common cancer in women worldwide. Despite the information provided by anatomopathological assessment and molecular markers (such as receptor expression ER, PR, HER2), breast cancer therapies and prognostics depend on the metabolic properties of tumor cells. However, metabolomics have not provided a robust and congruent biomarker yet, likely because individual metabolite contents are insufficient to encapsulate all of the alterations in metabolic fluxes. Here, we took...[Show more]

CollectionsANU Research Publications
Date published: 2016-09-28
Type: Journal article
Source: Scientific reports
DOI: 10.1038/srep34251
Access Rights: Open Access


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