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Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest

Santa-Gonzalez, Gloria A; Gomez-Molina, Andrea; Arcos-Burgos, Mauricio; Meyer, Joel N; Camargo, Mauricio

Description

Many environmental and physiological stresses are chronic. Thus, cells are constantly exposed to diverse types of genotoxic insults that challenge genome stability, including those that induce oxidative DNA damage. However, most in vitro studies that model cellular response to oxidative stressors employ short exposures and/or acute stress models. In this study, we tested the hypothesis that chronic and repeated exposure to a micromolar concentration of hydrogen peroxide (H2O2) could activate...[Show more]

CollectionsANU Research Publications
Date published: 2016-10
Type: Journal article
URI: http://hdl.handle.net/1885/146686
Source: Redox biology
DOI: 10.1016/j.redox.2016.07.004

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