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α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

Enriori, Pablo J; Chen, Weiyi; Garcia-Rudaz, Maria C; Grayson, Bernadette E; Evans, Anne E; Comstock, Sarah M; Gebhardt, Ursel; Müller, Hermann L; Reinehr, Thomas; Henry, Belinda A; Brown, Russell D; Bruce, Clinton R; Simonds, Stephanie E; Litwak, Sara A; McGee, Sean L; Luquet, Serge; Martinez, Sarah; Jastroch, Martin; Tschöp, Matthias H; Watt, Matthew J; Clarke, Iain J; Roth, Christian L; Grove, Kevin L; Cowley, Michael A

Description

OBJECTIVE Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH. METHODS We established glucose-stimulated α-MSH secretion using humans,...[Show more]

CollectionsANU Research Publications
Date published: 2016-08-05
Type: Journal article
URI: http://hdl.handle.net/1885/146683
Source: Molecular metabolism
DOI: 10.1016/j.molmet.2016.07.009

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