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Vaccine-induced protection against orthopoxvirus infection Is mediated through the combined functions of CD4 T cell-dependent antibody and CD8 T cell responses

Chaudhri, Geeta; Tahiliani, Vikas; Eldi, Preethi; Karupiah, Gunasegaran


Antibody production by B cells in the absence of CD4 T cell help has been shown to be necessary and sufficient for protection against secondary orthopoxvirus (OPV) infections. This conclusion is based on short-term depletion of leukocyte subsets in vaccinated animals, in addition to passive transfer of immune serum to naive hosts that are subsequently protected from lethal orthopoxvirus infection. Here, we show that CD4 T cell help is necessary for neutralizing antibody production and virus...[Show more]

CollectionsANU Research Publications
Date published: 2015-02
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.02572-14


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