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AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

Kang, Sun Woo Sophie; Haydar, Ghada; Taniane, Caitlin; Farrell, Geoffrey; Arias, Irwin M; Lippincott-Schwartz, Jennifer; Fu, Dong


Mitochondrial damage is the major factor underlying drug-induced liver disease but whether conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage is unclear. A key molecule regulating mitochondria quality control is AMP activated kinase (AMPK). When activated, AMPK causes mitochondria to elongate/fuse and proliferate, with mitochondria now producing more ATP and less reactive oxygen species. Autophagy is also triggered, a process capable of removing...[Show more]

CollectionsANU Research Publications
Date published: 2016-10-28
Type: Journal article
Source: PloS one
DOI: 10.1371/journal.pone.0165638
Access Rights: Open Access


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