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Trafficking of the exported P. falciparum chaperone PfHsp70x

Rhiel, Manuel; Bittl, Verena; Tribensky, Anke; Charnaud, Sarah C; Strecker, Maja; Müller, Sebastian; Lanzer, Michael; Sanchez, Cecilia; Schaeffer-Reiss, Christine; Westermann, Benoit; Crabb, Brendan S; Gilson, Paul R; Külzer, Simone; Przyborski, Jude M

Description

Plasmodium falciparum extensively modifies its chosen host cell, the mature human erythrocyte. This remodelling is carried out by parasite-encoded proteins that are exported into the host cell. To gain access to the human red blood cell, these proteins must cross the parasitophorous vacuole, a membrane bound compartment surrounding the parasite that is generated during the invasion process. Many exported proteins carry a so-called PEXEL/HT signal that directs their transport. We recently...[Show more]

CollectionsANU Research Publications
Date published: 2016-11-08
Type: Journal article
URI: http://hdl.handle.net/1885/146279
Source: Scientific reports
DOI: 10.1038/srep36174

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