Trafficking of the exported P. falciparum chaperone PfHsp70x
Rhiel, Manuel; Bittl, Verena; Tribensky, Anke; Charnaud, Sarah C; Strecker, Maja; Müller, Sebastian; Lanzer, Michael; Sanchez, Cecilia; Schaeffer-Reiss, Christine; Westermann, Benoit; Crabb, Brendan S; Gilson, Paul R; Külzer, Simone; Przyborski, Jude M
Plasmodium falciparum extensively modifies its chosen host cell, the mature human erythrocyte. This remodelling is carried out by parasite-encoded proteins that are exported into the host cell. To gain access to the human red blood cell, these proteins must cross the parasitophorous vacuole, a membrane bound compartment surrounding the parasite that is generated during the invasion process. Many exported proteins carry a so-called PEXEL/HT signal that directs their transport. We recently...[Show more]
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