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A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice

Huang, Hong Ming; Bauer, Denis C; Lelliott, Patrick M; Greth, Andreas; McMorran, Brendan; Foote, Simon J; Burgio, Gaetan

Description

Genetic defects in various red blood cell (RBC) cytoskeletal proteins have been long associated with changes in susceptibility towards malaria infection. In particular, while ankyrin (Ank-1) mutations account for approximately 50% of hereditary spherocytosis (HS) cases, an association with malaria is not well-established, and conflicting evidence has been reported. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced ankyrin mutation MRI61689 that gives rise to two different ankyrin...[Show more]

CollectionsANU Research Publications
Date published: 2016-11-16
Type: Journal article
URI: http://hdl.handle.net/1885/146244
Source: Scientific reports
DOI: 10.1038/srep37197
Access Rights: Open Access

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