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Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Fletcher, Sabine; Lucantoni, Leonardo; Sykes, Melissa L; Jones, Amy J; Holleran, John P; Saliba, Kevin; Avery, Vicky M


BACKGROUND In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite's known ability to develop drug resistance. Another desirable aspect is efficacy against gametocytes, the sexual developmental stage of the parasite which enables the transmission through Anopheles vectors. Using a chemical rescue approach, we previously identified compounds targeting Plasmodium...[Show more]

CollectionsANU Research Publications
Date published: 2016-11-17
Type: Journal article
Source: Parasites & vectors
DOI: 10.1186/s13071-016-1860-3
Access Rights: Open Access


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