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Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome

Trend, Stephanie; Jones, Anderson P; Cha, Lilian; Byrne, Scott N; Geldenhuys, Sian; Fabis-Pedrini, Marzena J; Carroll, William M; Cole, Judith M; Booth, David R; Lucas, Robyn M; Kermode, Allan G; French, Martyn A; Hart, Prue H


Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede a diagnosis of multiple sclerosis (MS). Therefore, studying individuals with CIS may lead to breakthroughs in understanding the development and pathogenesis of MS. In this study, serum levels of immunoglobulin (Ig)G, IgA, IgM, and IgG1-4 were measured in 20 people with CIS and compared with those in 10 healthy controls (HC) and 8 people with MS. Serum Ig levels in individuals with CIS were compared...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-13
Type: Journal article
Source: Frontiers in immunology
DOI: 10.3389/fimmu.2018.01590
Access Rights: Open Access


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