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Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome

Natoli, Riccardo; Mason, Elizabeth; Jiao, Haihan; Chuah, Aaron; Patel, Hardip; Fernando, Nilisha; Valter, Krisztina; Wells, Christine A; Provis, Jan; Rutar, Matt


The pathogenesis of many retinal degenerations, such as age-related macular degeneration (AMD), is punctuated by an ill-defined network of sterile inflammatory responses. The delineation of innate and adaptive immune milieu among the broad leukocyte infiltrate, and the gene networks, which construct these responses, are poorly described in the eye. Using photo-oxidative damage in a rodent model of subretinal inflammation, we employed a novel RNA-sequencing framework to map the global gene...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-18
Type: Journal article
Source: Frontiers in immunology
DOI: 10.3389/fimmu.2018.01666
Access Rights: Open Access


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