Skip navigation
Skip navigation

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

Bröer, Angelika; Fairweather, Stephen; Bröer, Stefan

Description

The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinical in vivo models. To test its specificity, we deleted ASCT2 in two human cancer cell lines. Surprisingly, growth of parental and ASCT2-knockout cells was equally sensitive to AABA compounds. AABA...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-19
Type: Journal article
URI: http://hdl.handle.net/1885/146080
Source: Frontiers in pharmacology
DOI: 10.3389/fphar.2018.00785
Access Rights: Open Access

Download

File Description SizeFormat Image
01 Broer A et al Disruption of amino 2018.pdf423.65 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator