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Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

Bröer, Angelika; Fairweather, Stephen; Bröer, Stefan


The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinical in vivo models. To test its specificity, we deleted ASCT2 in two human cancer cell lines. Surprisingly, growth of parental and ASCT2-knockout cells was equally sensitive to AABA compounds. AABA...[Show more]

CollectionsANU Research Publications
Date published: 2018-07-19
Type: Journal article
Source: Frontiers in pharmacology
DOI: 10.3389/fphar.2018.00785
Access Rights: Open Access


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