Non-Immune Islet beta cell susceptibility to failure in NODk mice
NODk mice are congenic for the protective MHC H2k (Idd 1 locus) and unlike NOD mice do not develop autoimmune diabetes. The aim of the study was to determine if NODk β-cells have a non-immune islet beta-cell defect that may be revealed by stressing the islets with high fat diet (HFD). B10k (B10.Br mice with H2k haplotype) and Balb/c mice were used as comparator groups. Male NODk, B10k and Balb/c mice were fed chow or HF diets from 4 weeks of age...[Show more]
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