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Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

Cacho, Ralph A.; Tang, Yi; Chooi, Yit-Heng


Genomics has revolutionized the research on fungal secondary metabolite (SM) biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific SM compound, the important first step is often to find the genes that responsible for its synthesis. The accessibility to fungal genome sequences allows the bypass of the cumbersome traditional library construction and screening approach. The advance in next-generation sequencing (NGS) technologies have further...[Show more]

CollectionsANU Research Publications
Date published: 2015-01-14
Type: Journal article
Source: Frontiers in Microbiology
DOI: 10.3389/fmicb.2014.00774


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