New aspects of ZIC2-associated Holoprosencephaly
Holoprosencephaly (HPE) occurs due to incomplete division of the developing forebrain along the embryonic midline, resulting in a failure to form two distinct cerebral hemispheres. Affecting 1/250 human conceptuses, HPE is a leading cause of pre- and post-natal morbidity and mortality. Currently, pathogenic mutations in the coding region of fifteen genes have been implicated in both classic and middle interhemispheric variants of HPE. Mutation of ZIC2 accounts...[Show more]
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