Using TALENs to Knockout H2A.Lap1 Function in Mice
The Tremethick laboratory in 2012 discovered a new mouse histone variant, which was designated H2A.Lap1 (Lack of an acidic patch), which, in the adult, is uniquely expressed in the testis and the brain. It was proposed that in the testis, H2A.Lap1 is involved in a new mechanism of gene regulation whereby H2A.Lap1 co-ordinately activates the expression of many genes by being targeted to and directly opening the chromatin region encompassing their transcription...[Show more]
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