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C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition

Beard, Nicole A.; Dulhunty, Angela F.


BACKGROUND Skeletal muscle function depends on calcium signaling proteins in the sarcoplasmic reticulum (SR), including the calcium-binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channel, and skeletal triadin 95 kDa (trisk95) and junctin, proteins that bind to calsequestrin type 1 (CSQ1) and ryanodine receptor type 1 (RyR1). CSQ1 inhibits RyR1 and communicates store calcium load to RyR1 channels via trisk95 and/or junctin. METHODS In this manuscript, we test...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-22
Type: Journal article
Source: Skeletal Muscle
DOI: 10.1186/s13395-015-0029-7


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