Skip navigation
Skip navigation

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition

Beard, Nicole A.; Dulhunty, Angela F.

Description

BACKGROUND Skeletal muscle function depends on calcium signaling proteins in the sarcoplasmic reticulum (SR), including the calcium-binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channel, and skeletal triadin 95 kDa (trisk95) and junctin, proteins that bind to calsequestrin type 1 (CSQ1) and ryanodine receptor type 1 (RyR1). CSQ1 inhibits RyR1 and communicates store calcium load to RyR1 channels via trisk95 and/or junctin. METHODS In this manuscript, we test...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-22
Type: Journal article
URI: http://hdl.handle.net/1885/14339
Source: Skeletal Muscle
DOI: 10.1186/s13395-015-0029-7

Download

File Description SizeFormat Image
Beard and Dulhunty C-terminal Residues 2015.pdf3.41 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator