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LRGUK-1 is required for basal body and Manchette function during spermatogenesis and male fertility

Liu, Yan; DeBoer, Kathleen; de Kretser, David M.; O’Donnell, Liza; O’Connor, Anne E.; Merriner, D. Jo; Okuda, Hidenobu; Whittle, Belinda; Jans, David A.; Efthymiadis, Athina; McLachlan, Robert I.; Ormandy, Christopher J.; Goodnow, Chris C.; Jamsai, Duangporn; O’Bryan, Moira K.


Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OAT men a precise diagnosis cannot be provided. Here we demonstrate that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK-1) is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-17
Type: Journal article
Source: PLOS Genetics
DOI: 10.1371/journal.pgen.1005090


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