Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria
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Bijker, Else M; Nganou-Makamdop, Krystelle; van Gemert, Geert-Jan; Zavala, Fidel; Cockburn, Ian; Sauerwein, Robert W
Description
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria. In humans, CPS-CQ is strikingly more efficient than immunization with radiation attenuated sporozoites (RAS), raising the hypothesis that this might be partially due to CQ. Chloroquine, an established anti-malarial drug, is also well known for its immune modulating properties including improvement of cross-presentation. The aim...[Show more]
Collections | ANU Research Publications |
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Date published: | 2015-03-26 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/14316 |
Source: | Malaria Journal |
DOI: | 10.1186/s12936-015-0626-2 |
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Bijker et al Studying the Effect of Chloroquine 2015.pdf | 852.37 kB | Adobe PDF | ![]() |
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