Bijker, Else M; Nganou-Makamdop, Krystelle; van Gemert, Geert-Jan; Zavala, Fidel; Cockburn, Ian; Sauerwein, Robert W
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria. In humans, CPS-CQ is strikingly more efficient than immunization with radiation attenuated sporozoites (RAS), raising the hypothesis that this might be partially due to CQ. Chloroquine, an established anti-malarial drug, is also well known for its immune modulating properties including improvement of cross-presentation. The aim...[Show more]
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