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A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum

Marchetti, Rosa V.; Lehane, Adele M.; Shafik, Sarah H.; Winterberg, Markus; Martin, Rowena E.; Kirk, Kiaran

Description

The intraerythrocytic malaria parasite relies primarily on glycolysis to fuel its rapid growth and reproduction. The major byproduct of this metabolism, lactic acid, is extruded into the external medium. In this study, we show that the human malaria parasite Plasmodium falciparum expresses at its surface a member of the microbial formate-nitrite transporter family (PfFNT), which, when expressed in Xenopus laevis oocytes, transports both formate and lactate. The transport characteristics of...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-31
Type: Journal article
URI: http://hdl.handle.net/1885/14283
Source: Nature Communications
DOI: 10.1038/ncomms7721

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