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Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib

Lee, Chee Khoon; Goldstein, David; Gibbs, Emma; Joensuu, Heikki; Zalcberg, John; Verweij, Jaap; Casali, Paolo G; Maki, Robert G; Cioffi, Angela; McArthur, Grant; Lord, Sarah J; Yip, Desmond; Kanjanapan, Yada; Rutkowski, Piotr

Description

PURPOSE Metastatic gastrointestinal stromal tumour (GIST) is generally an incurable disease with variable response to imatinib. We aimed to develop prognostic nomograms to predict overall survival (OS) and progression-free survival (PFS) for patients treated with imatinib. METHODS Nomograms were developed in a training cohort (n=330) of patients treated in a randomised trial (EORTC-ISG-AGITG 62005 phase III study) using Cox regression models, and validated in patients (n=236) treated in routine...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-19
Type: Journal article
URI: http://hdl.handle.net/1885/14195
Source: European Journal of Cancer
DOI: 10.1016/j.ejca.2015.02.015

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