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Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib

Lee, Chee Khoon; Goldstein, David; Gibbs, Emma; Joensuu, Heikki; Zalcberg, John; Verweij, Jaap; Casali, Paolo G; Maki, Robert G; Cioffi, Angela; McArthur, Grant; Lord, Sarah J; Yip, Desmond; Kanjanapan, Yada; Rutkowski, Piotr


PURPOSE Metastatic gastrointestinal stromal tumour (GIST) is generally an incurable disease with variable response to imatinib. We aimed to develop prognostic nomograms to predict overall survival (OS) and progression-free survival (PFS) for patients treated with imatinib. METHODS Nomograms were developed in a training cohort (n=330) of patients treated in a randomised trial (EORTC-ISG-AGITG 62005 phase III study) using Cox regression models, and validated in patients (n=236) treated in routine...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-19
Type: Journal article
Source: European Journal of Cancer
DOI: 10.1016/j.ejca.2015.02.015


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