Skip navigation
Skip navigation

Synergistic cooperation and crosstalk betweenMYD88L265Pand mutations that dysregulate CD79B and surface IgM

Wang, James Q; Jeelall, Yogesh S; Humburg, Peter; Batchelor, Emma L; Kaya, Sarp M; Yoo, Hee Min; Goodnow, Christopher C; Horikawa, Keisuke

Description

CD79B andMYD88mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences ofCD79BandMYD88L265Pmutations individually and combined in normal activated mouse B lymphocytes.CD79Bmutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expressingMYD88L265Pdecreased surface IgM coupled with...[Show more]

CollectionsANU Research Publications
Date published: 2017-09-04
Type: Journal article
URI: http://hdl.handle.net/1885/141171
Source: The Journal of experimental medicine
DOI: 10.1084/jem.20161454

Download

File Description SizeFormat Image
Wang_Synergistic_2017.pdf2.53 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator