Synergistic cooperation and crosstalk betweenMYD88L265Pand mutations that dysregulate CD79B and surface IgM
CD79B andMYD88mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences ofCD79BandMYD88L265Pmutations individually and combined in normal activated mouse B lymphocytes.CD79Bmutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expressingMYD88L265Pdecreased surface IgM coupled with...[Show more]
|Collections||ANU Research Publications|
|Source:||The Journal of experimental medicine|
|Wang_Synergistic_2017.pdf||2.53 MB||Adobe PDF|
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