EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Fu, Nai Yang; Rios, Anne C.; Pal, Bhupinder; Soetanto, Rina; Lun, Aaron T. L.; Liu, Kevin; Beck, Tamara; Best, Sarah A.; Vaillant, François; Bouillet, Philippe; Strasser, Andreas; Preiss, Thomas; Smyth, Gordon K.; Lindeman, Geoffrey J.; Visvader, Jane E.
Expansion and remodelling of the mammary epithelium requires a tight balance between cellular proliferation, differentiation and death. To explore cell survival versus cell death decisions in this organ, we deleted the pro-survival gene Mcl-1 in the mammary epithelium. Mcl-1 was found to be essential at multiple developmental stages including morphogenesis in puberty and alveologenesis in pregnancy. Moreover, Mcl-1-deficient basal cells were virtually devoid of repopulating activity, suggesting...[Show more]
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|Source:||Nature Cell Biology|