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Manufacture of immunoglobulin products for patients with primary antibody deficiencies - the effect of processing conditions on product safety and efficacy

Farrugia, Albert; Quinti, Isabella

Description

Early preparations of immunoglobulin (Ig) manufactured from human plasma by ethanol (Cohn) fractionation were limited in their usefulness for substitution therapy in patients with primary antibody deficiencies (PAD), as Ig aggregates formed during manufacture resulted in severe systemic reactions in patients when given intravenously. Developments in manufacturing technology obviated this problem through the capacity to produce concentrated solutions of intact monomeric Ig, revolutionizing PAD...[Show more]

CollectionsANU Research Publications
Date published: 2014-12-23
Type: Journal article
URI: http://hdl.handle.net/1885/14003
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2014.00665

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