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First-in-human trial of a novel suprachoroidal retinal prosthesis

Ayton, Lauren N.; Blamey, Peter J.; Guymer, Robyn H.; Luu, Chi D.; Nayagam, David A. X.; Sinclair, Nicholas C.; Shivdasani, Mohit N.; Yeoh, Jonathan; McCombe, Mark F.; Briggs, Robert J.; Opie, Nicholas L.; Villalobos, Joel; Dimitrov, Peter N.; Varsamidis, Mary; Petoe, Matthew A.; McCarthy, Chris D.; Walker, Janine G.; Barnes, Nick; Burkitt, Anthony Neville; Williams, Chris E.; Shepherd, Robert K.; Allen, Penelope J.

Description

UNLABELLED Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients,...[Show more]

dc.contributor.authorAyton, Lauren N.
dc.contributor.authorBlamey, Peter J.
dc.contributor.authorGuymer, Robyn H.
dc.contributor.authorLuu, Chi D.
dc.contributor.authorNayagam, David A. X.
dc.contributor.authorSinclair, Nicholas C.
dc.contributor.authorShivdasani, Mohit N.
dc.contributor.authorYeoh, Jonathan
dc.contributor.authorMcCombe, Mark F.
dc.contributor.authorBriggs, Robert J.
dc.contributor.authorOpie, Nicholas L.
dc.contributor.authorVillalobos, Joel
dc.contributor.authorDimitrov, Peter N.
dc.contributor.authorVarsamidis, Mary
dc.contributor.authorPetoe, Matthew A.
dc.contributor.authorMcCarthy, Chris D.
dc.contributor.authorWalker, Janine G.
dc.contributor.authorBarnes, Nick
dc.contributor.authorBurkitt, Anthony Neville
dc.contributor.authorWilliams, Chris E.
dc.contributor.authorShepherd, Robert K.
dc.contributor.authorAllen, Penelope J.
dc.date.accessioned2015-06-17T02:41:14Z
dc.date.available2015-06-17T02:41:14Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/13985
dc.description.abstractUNLABELLED Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration. TRIAL REGISTRATION Clinicaltrials.gov NCT01603576.
dc.description.sponsorshipThis research was supported by the Australian Research Council (http://www.arc.gov. au) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA). The Centre for Eye Research Australia (CERA) and the Bionics Institute receive Operational Infrastructure Support from the Victorian Government. CERA is also supported by a NH&MRC Centre for Clinical Research Excellence (#529923) grant – Translational Clinical Research in Major Eye Diseases (https://www.nhmrc.gov.au). RG is supported by an NHMRC practitioner fellowship (#529905). NICTA is funded by the Australian Government through the Department of Communications and the Australian Research Council through the ICT Centre of Excellence Program (http://www.arc.gov.au/ncgp/centres/ centres_nicta.htm). Additional support for this project came from the Ian Potter Foundation (http:// www.ianpotter.org.au), John T. Reid Charitable Trusts (http://www.johntreidtrusts.com.au), Retina Australia (http://www.retinaaustralia.com.au) and the Bertalli Family Foundation (http://fbe.unimelb. edu.au/scholarships/opportunities/undergraduate/ the_bertalli_family_foundation_scholarships).
dc.format26 pages
dc.publisherPublic Library of Science
dc.rights© 2014 Ayton et al. This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS ONE
dc.titleFirst-in-human trial of a novel suprachoroidal retinal prosthesis
dc.typeJournal article
local.identifier.citationvolume9
dcterms.dateAccepted2014-11-18
dc.date.issued2014-12-18
local.identifier.absfor080101 - Adaptive Agents and Intelligent Robotics
local.identifier.absfor080104 - Computer Vision
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.ariespublicationa383154xPUB2009
local.publisher.urlhttps://www.plos.org/
local.type.statusPublished Version
local.contributor.affiliationMcCarthy, C. D., National Institute for Mental Health Research, The Australian National University
local.contributor.affiliationWalker, J. G., National Institute for Mental Health Research, The Australian National University
local.contributor.affiliationBarnes, N., National Institute for Mental Health Research, The Australian National University
dc.relationhttp://purl.org/au-research/grants/nhmrc/529905
local.identifier.essn1932-6203
local.bibliographicCitation.issue12
local.bibliographicCitation.startpagee115239
local.identifier.doi10.1371/journal.pone.0115239
dc.date.updated2015-12-10T11:32:20Z
local.identifier.scopusID2-s2.0-84919476329
CollectionsANU Research Publications

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