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Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke

Somaa, Fahad A; Wang, Ting-Yi; Niclis, Jonathan C; Bruggeman, Kiara; Kauhausen, Jessica A; Guo, Haoyao; McDougall, Stuart; Williams, Richard J; Nisbet, David; Thompson, Lachlan H; Parish, Clare L

Description

Stem cell transplants offer significant hope for brain repair following ischemic damage. Pre-clinical work suggests that therapeutic mechanisms may be multi-faceted, incorporating bone-fide circuit reconstruction by transplanted neurons, but also protection/regeneration of host circuitry. Here, we engineered hydrogel scaffolds to form "bio-bridges" within the necrotic lesion cavity, providing physical and trophic support to transplanted human embryonic stem cell-derived cortical progenitors,...[Show more]

CollectionsANU Research Publications
Date published: 2017-08-22
Type: Journal article
URI: http://hdl.handle.net/1885/139537
Source: Cell reports
DOI: 10.1016/j.celrep.2017.07.069

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