Somaa, Fahad A; Wang, Ting-Yi; Niclis, Jonathan C; Bruggeman, Kiara; Kauhausen, Jessica A; Guo, Haoyao; McDougall, Stuart; Williams, Richard J; Nisbet, David; Thompson, Lachlan H; Parish, Clare L
Stem cell transplants offer significant hope for brain repair following ischemic damage. Pre-clinical work suggests that therapeutic mechanisms may be multi-faceted, incorporating bone-fide circuit reconstruction by transplanted neurons, but also protection/regeneration of host circuitry. Here, we engineered hydrogel scaffolds to form "bio-bridges" within the necrotic lesion cavity, providing physical and trophic support to transplanted human embryonic stem cell-derived cortical progenitors,...[Show more]
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