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The impact of aging on subregions of the hippocampal complex in healthy adults

Kurth, Florian; Cherbuin, Nicolas; Luders, Eileen

Description

The hippocampal complex, an anatomical composite of several subregions, is known to decrease in size with increasing age. However, studies investigating which subregions are particularly prone to age-related tissue loss revealed conflicting findings. Possible reasons for such inconsistencies may reflect differences between studies in terms of the cohorts examined or techniques applied to define and measure hippocampal subregions. In the present study, we enhanced conventional MR-based...[Show more]

dc.contributor.authorKurth, Florian
dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorLuders, Eileen
dc.date.accessioned2018-01-19T01:31:54Z
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/1885/139462
dc.description.abstractThe hippocampal complex, an anatomical composite of several subregions, is known to decrease in size with increasing age. However, studies investigating which subregions are particularly prone to age-related tissue loss revealed conflicting findings. Possible reasons for such inconsistencies may reflect differences between studies in terms of the cohorts examined or techniques applied to define and measure hippocampal subregions. In the present study, we enhanced conventional MR-based information with microscopically defined cytoarchitectonic probabilities to investigate aging effects on the hippocampal complex in a carefully selected sample of 96 healthy subjects (48 males/48 females) aged 18-69 years. We observed significant negative correlations between age and volumes of the cornu ammonis, fascia dentata, subiculum, and hippocampal-amygdaloid transition area, but not the entorhinal cortex. The estimated age-related annual atrophy rates were most pronounced in the left and right subiculum with -0.23% and -0.22%, respectively. These findings suggest age-related atrophy of the hippocampal complex overall, but with differential effects in its subregions. If confirmed in future studies, such region-specific information may prove useful for the assessment of diseases and disorders known to modulate age-related hippocampal volume loss.
dc.description.sponsorshipNC is funded by Australian Research Council Future fellowship number 120100227. EL is funded by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under award number R01HD081720 and further supported by the Cousins Center for Psychoneuroimmunology at the University of California, Los Angeles (UCLA).
dc.format.mimetypeapplication/pdf
dc.publisherElsevier
dc.rights© 2017 Elsevier B.V.
dc.sourceNeuroImage
dc.subjectaging
dc.subjectbrain
dc.subjectgender
dc.subjecthippocampus
dc.subjectmri
dc.subjectsex
dc.titleThe impact of aging on subregions of the hippocampal complex in healthy adults
dc.typeJournal article
local.identifier.citationvolume163
dc.date.issued2017-12
local.publisher.urlhttps://www.elsevier.com/
local.type.statusAccepted Version
local.contributor.affiliationCherbuin, N., Centre for Research on Ageing Health and Wellbeing, The Australian National University
local.contributor.affiliationLuders, E., Centre for Research on Ageing Health and Wellbeing, The Australian National University
dc.relationhttp://purl.org/au-research/grants/arc/FT120100227
local.identifier.essn1095-9572
local.bibliographicCitation.startpage296
local.bibliographicCitation.lastpage300
local.identifier.doi10.1016/j.neuroimage.2017.09.016
dcterms.accessRightsOpen Access
dc.provenancehttp://www.sherpa.ac.uk/romeo/issn/1053-8119/..."Author's post-print on open access repository after an embargo period of between 12 months and 48 months" from SHERPA/RoMEO site (as at 19/01/18).
CollectionsANU Research Publications

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