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Hippocampal activation and memory performance in schizophrenia depend on strategy use in a virtual maze

Wilkins, Leanne K.; Girard, Todd A.; Herdman, Katherine A.; Christensen, Bruce; King, Jelena; Kiang, Michael; Bohbot, Veronique D.


Different strategies may be spontaneously adopted to solve most navigation tasks. These strategies are associated with dissociable brain systems. Here, we use brain-imaging and cognitive tasks to test the hypothesis that individuals living with Schizophrenia Spectrum Disorders (SSD) have selective impairment using a hippocampal-dependent spatial navigation strategy. Brain activation and memory performance were examined using functional magnetic resonance imaging (fMRI) during the 4-on-8 virtual...[Show more]

CollectionsANU Research Publications
Date published: 2017-10-30
Type: Journal article
Source: Psychiatry research
DOI: 10.1016/j.pscychresns.2017.07.007
Access Rights: Open Access


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