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Plasmodium falciparum exported protein PFE60 influences Maurer's clefts architecture and virulence complex composition

Zhang, Meng; Faou, Pierre; Maier, Alexander G; Rug, Melanie

Description

Plasmodium falciparum, the most lethal malaria parasite species for humans, vastly remodels the mature erythrocyte host cell upon invasion for its own survival. Maurer's clefts (MC) are membraneous structures established by the parasite in the cytoplasm of infected cells. These organelles are deemed essential for trafficking of virulence complex proteins. The display of the major virulence protein, P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of the infected red blood...[Show more]

CollectionsANU Research Publications
Date published: 2018-01
Type: Journal article
URI: http://hdl.handle.net/1885/139096
Source: International journal for parasitology
DOI: 10.1016/j.ijpara.2017.09.003

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