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Photobiomodulation with 670 nm light ameliorates Müller cell-mediated activation of microglia and macrophages in retinal degeneration

Lu, Yen-Zhen; Natoli, Riccardo; Madigan, Michele; Fernando, Nilisha; Saxena, Kartik; Aggio-Bruce, Riemke; Jiao, Haihan; Provis, Jan; Valter, Krisztina


Müller cells, the supporting cells of the retina, play a key role in responding to retinal stress by releasing chemokines, including CCL2, to recruit microglia and macrophages (MG/MΦ) into the damaged retina. Photobiomodulation (PBM) with 670 nm light has been shown to reduce inflammation in models of retinal degeneration. In this study, we aimed to investigate whether 670 nm light had an effect on Müller cell-initiated inflammation under retinal photo-oxidative damage (PD) in vivo and...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Experimental eye research
DOI: 10.1016/j.exer.2017.09.002
Access Rights: Open Access


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