Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells
ZSTK474 is a potent phosphoinositide 3-kinase (PI3K) inhibitor that reduces cell proliferation via G1-arrest. However, there is little information on the susceptibility of this anticancer drug to resistance conferred by the multidrug pumps P-glycoprotein (ABCB1) and ABCG2. We have demonstrated that ZSTK474 generated cytotoxicity in cells over-expressing either pump with potency similar to that in drug sensitive cells. In addition, the co-administration of ZSTK474 with the cytotoxic anti-cancer...[Show more]
|Collections||ANU Research Publications|
|Source:||European journal of pharmacology|
|1-s2.0-S0014299917305769-main.pdf||1.22 MB||Adobe PDF|
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