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Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells

Muthiah, Divya; Callaghan, Richard


ZSTK474 is a potent phosphoinositide 3-kinase (PI3K) inhibitor that reduces cell proliferation via G1-arrest. However, there is little information on the susceptibility of this anticancer drug to resistance conferred by the multidrug pumps P-glycoprotein (ABCB1) and ABCG2. We have demonstrated that ZSTK474 generated cytotoxicity in cells over-expressing either pump with potency similar to that in drug sensitive cells. In addition, the co-administration of ZSTK474 with the cytotoxic anti-cancer...[Show more]

CollectionsANU Research Publications
Date published: 2017-11-15
Type: Journal article
Source: European journal of pharmacology
DOI: 10.1016/j.ejphar.2017.09.001
Access Rights: Open Access


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