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A new look at an old view of denaturant induced protein unfolding

Hall, Damien; Kinjo, Akira; Goto, Yuji

Description

We re-examine a site-binding approach independently proposed by Schellman (Schellman, J.A. (1958) Compt. rend. Lab. Carlsberg Ser. Chim. 30, 439-449) and Aune and Tanford (Aune, K.C. and Tanford, D. (1969) Biochemistry, 8, 4586-4590) for explicitly including the denaturant concentration within the protein unfolding equilibrium. We extend and formalize the approach through development of a multi-dimensional analytical model in which the folding reaction coordinate is defined by the number of...[Show more]

CollectionsANU Research Publications
Date published: 2018-02-01
Type: Journal article
URI: http://hdl.handle.net/1885/139065
Source: Analytical biochemistry
DOI: 10.1016/j.ab.2017.11.011

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