Skip navigation
Skip navigation

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

Moily, Nagaraj S.; Ormsby, Angelique R.; Stojilovic, Aleksandar; Ramdzan, Yasmin M.; Diesch, Jeannine; Hannan, Ross D.; Zajac, Michelle S.; Hannan, Anthony J.; Oshlack, Alicia; Hatters, Danny M.


Huntington's disease is caused by polyglutamine (polyQ)-expansion mutations in the CAG tandem repeat of the Huntingtin gene. The central feature of Huntington's disease pathology is the aggregation of mutant Huntingtin (Htt) protein into micrometer-sized inclusion bodies. Soluble mutant Htt states are most proteotoxic and trigger an enhanced risk of death whereas inclusions confer different changes to cellular health, and may even provide adaptive responses to stress. Yet the molecular...[Show more]

CollectionsANU Research Publications
Date published: 2017-09
Type: Journal article
Source: Molecular and cellular neurosciences
DOI: 10.1016/j.mcn.2017.07.004
Access Rights: Open Access


File Description SizeFormat Image
01 Moily N S et al Transcriptional profiles for distinct 2017.pdf393.13 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator